Articles

Correction to: A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets

The corresponding author, Mohammad Hosein Farzaei, affiliation is Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. The correct spelling of the 7th author su...

Authors: Yasamin Davatgaran Taghipour, Roodabeh Bahramsoltani, André M. Marques, Rozita Naseri, Roja Rahimi, Pouya Haratipour, Amin Iranpanah, Mohammad Hosein Farzaei and Mohammad Abdollahi

Application of nanostructured lipid carriers: the prolonged protective effects for sesamol in in vitro and in vivo models of ischemic stroke via activation of PI3K signalling pathway

Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, sesamol, has shown promising antioxidant and neuroprotective effects, however, fast clearance may negatively a...

Authors: Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand, Ahmad-Reza Dehpour, Morteza Azhdarzadeh and Meshkat Dinarvand

Effect of memantine on post-operative cognitive dysfunction after cardiac surgeries: a randomized clinical trial

Post-operative cognitive dysfunction (POCD) is an important complication of cardiac surgeries. Glutamate plays a critical role in physiologic and pathologic conditions in the brain. Due to the role of glutamat...

Authors: Saba Ghaffary, Padideh Ghaeli, Azita Hajhossein Talasaz, Abbasali Karimi, Maryam Noroozian, Abbas Salehiomran and Arash Jalali

Linagliptin versus sitagliptin in patients with type 2 diabetes mellitus: a network meta-analysis of randomized clinical trials

Diabetes is one of the most common chronic and costly diseases worldwide and type 2 diabetes is the most common type which accounts for about 90% of cases with diabetes. New medication-therapy regimens such as...

Authors: Khosro Keshavarz, Farhad Lotfi, Ehsan Sanati, Mahmood Salesi, Amir Hashemi-Meshkini, Mojtaba Jafari, Mohammad M. Mojahedian, Behzad Najafi and Shekoufeh Nikfar

Optimization and characterization of spray-dried IgG formulations: a design of experiment approach

The purpose of the present study is to optimize a spray-dried formulation as a model antibody regarding stability and aerodynamic property for further aerosol therapy of this group of macromolecules.

Authors: Homa Faghihi, Abdolhosein Rouholamini Najafabadi and Alireza Vatanara

Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway

Heqi San, a traditional Chinese medicine (TCM) has been reported to regulate hormone levels in patients with metabolic disease, suggesting a potential clinical application. In the current study, we aimed to el...

Authors: Hengxia Zhao, Daocheng Zhou, Ye Chen, Deliang Liu, Shufang Chu and Shimao Zhang

Sustained-release study on Exenatide loaded into mesoporous silica nanoparticles: in vitro characterization and in vivo evaluation

Exenatide (EXT), the first glucagon-like peptide-1 receptor agonist, has been approved as an adjunctive therapy for patients with type 2 diabetes. Due to EXT’s short half-life, EXT must be administrated by con...

Authors: Cuiwei Chen, Hongyue Zheng, Junjun Xu, Xiaowei Shi, Fanzhu Li and Xuanshen Wang

Formulation of an aloe-based product according to Iranian traditional medicine and development of its analysis method

Currently, people are more interested to traditional medicine. The traditional formulations should be converted to modern drug delivery systems to be more acceptable for the patients. In the present investigat...

Authors: Elham Moein, Homa Hajimehdipoor, Tayebeh Toliyat, Rasool Choopani and Maryam Hamzeloo-Moghadam

Pinus densiflora needle supercritical fluid extract suppresses the expression of pro-inflammatory mediators iNOS, IL-6 and IL-1β, and activation of inflammatory STAT1 and STAT3 signaling proteins in bacterial lipopolysaccharide-challenged murine macrophages

Regulation of a persistently-activated inflammatory response in macrophages is an important target for treatment of various chronic diseases. Pine needle extracts are well known to have potent immunomodulatory...

Authors: Thamizhiniyan Venkatesan, Young-Woong Choi, Jennifer Lee and Young-Kyoon Kim

Prediction of new Hsp90 inhibitors based on 3,4-isoxazolediamide scaffold using QSAR study, molecular docking and molecular dynamic simulation

Heat shock protein90 (Hsp90) are overexpressed in tumor cells, so the inhibition of the Hsp90 ATPase activity would be a significantly effective strategy in cancer therapy.

Authors: Maryam Abbasi, Hojjat Sadeghi-Aliabadi and Massoud Amanlou

Inhibition of mirtazapine metabolism by Ecstasy (MDMA) in isolated perfused rat liver model

Nowadays MDMA (3,4-methylendioxymethamphetamine), known as ecstasy, is widely abused among the youth because of euphoria induction in acute exposure. However, abusers are predisposed to depression in chronic c...

Authors: Sanaz Jamshidfar, Yalda H. Ardakani, Hoda Lavasani and Mohammadreza Rouini

Forensic toxicology analysis of self-poisoning suicidal deaths in Tehran, Iran; trends between 2011-2015

Suicide ranks among the top ten causes of death in all age groups all over the world. There are many methods for committing suicide including self-poisoning, firearm and hanging. The aim of the present study w...

Authors: Roya Kordrostami, Maryam Akhgari, Maryam Ameri, Masoud Ghadipasha and Kamran Aghakhani

Worldwide legislative challenges related to psychoactive drugs

The discovery of a “new” psychoactive substance is a relatively exceptional event, while the regulatory response usually involved the assessment of risks to public health and inclusion of the novel substance i...

Authors: Carolina Negrei, Bianca Galateanu, Miriana Stan, Cristian Balalau, Mircea Lucian Bogdan Dumitru, Eren Ozcagli, Concettina Fenga, Leda Kovatsi, Domniki Fragou and Aristidis Tsatsakis

^99mTc-radiolabeled GE11-modified peptide for ovarian tumor targeting

Ovarian cancer is a serious threat for women health and the early diagnosis of this cancer might improves the survival rate of patients. The use of the targeted radiopharmaceuticals could be a non-invasive and...

Authors: Najmeh Rahmanian, Seyed Jalal Hosseinimehr, Ali Khalaj, Zohreh Noaparast, Seyed Mohammad Abedi and Omid Sabzevari

Adverse drug reactions and kinetics of cisplatin excretion in urine of patients undergoing cisplatin chemotherapy and radiotherapy for head and neck cancer: a prospective study

Cisplatin is a high-potency anticancer agent; however, it causes significant adverse drug reactions (ADRs). Potential pharmacokinetic markers must be studied to predict or prevent cisplatin-induced ADRs and ac...

Authors: Marília Berlofa Visacri, Eder de Carvalho Pincinato, Graziele Baldan Ferrari, Júlia Coelho França Quintanilha, Priscila Gava Mazzola, Carmen Silvia Passos Lima and Patricia Moriel

Combination of sofosbuvir, pegylated-interferon and ribavirin for treatment of hepatitis C virus genotype 1 infection: a systematic review and meta-analysis

Hepatitis C virus (HCV) infection is an important cause of chronic liver disease which has been affected 3% of world’s population. Some studies have shown that adding Sofosbuvir (SOF), an HCV polymerase inhibi...

Authors: Fardin Dolatimehr, Hamidreza Karimi-Sari, Mohammad Saeid Rezaee-Zavareh, Seyed Moayed Alavian, Bita Behnava, Mohammad Gholami-Fesharaki and Heidar Sharafi

A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective

Physicians often come across with cases of vitamin K antagonists–dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagula...

Authors: Valery V. Wojciechowski, Daniela Calina, Konstantinos Tsarouhas, Alexander V. Pivnik, Alexander A. Sergievich, Vladimir V. Kodintsev, Ekaterina A. Filatova, Eren Ozcagli, Anca Oana Docea, Andreea Letitia Arsene, Eliza Gofita, Christina Tsitsimpikou, Aristidis M. Tsatsakis and Kirill S. Golokhvast

Health risks associated with the pharmaceuticals in wastewater

The overwhelming population growth in recent decades and water crisis along with limited and uneven geographical distribution of fresh water resources is a growing challenge for the economic and human developm...

Authors: Nasser Nassiri Koopaei and Mohammad Abdollahi

Carboxylate derivatives of tributyltin (IV) complexes as anticancer and antileishmanial agents

Tributyltin (IV) compounds are promising candidates for drug development. In the current study, we evaluated in-vitro and in-silico profile of carboxylate derivatives of tributyltin (IV) complexes.

Authors: Durdana Waseem, Arshad Farooq Butt, Ihsan-ul Haq, Moazzam Hussain Bhatti and Gul Majid Khan

Historical root of precision medicine: an ancient concept concordant with the modern pharmacotherapy

Pharmacogenomics and pharmacoproteomics are new sciences that their goal is achieving therapeutics with maximum results and minimal side effects for each individual due to the pattern of his genome and proteome.

Authors: Reihaneh Moeini, Zahra Memariani, Parvin Pasalar and Narjes Gorji

Thiolation of arabinoxylan and its application in the fabrication of controlled release mucoadhesive oral films

Mucoadhesion is an important property that helps oral drug delivery system to remain attached with buccal mucosa and hence to improve the delivery of the drug. The current study was designed to achieve the thi...

Authors: Muhammad Hanif and Muhammad Zaman

Histopathological study of cardiac lesions in methamphetamine poisoning-related deaths

Methamphetamine abuse is a worldwide health concern. Methamphetamine causes health hazards in many vital organs. It can cause damage to cardiac tissue via catecholamines release. Methamphetamine related deaths...

Authors: Maryam Akhgari, Homeira Mobaraki and Afshar Etemadi-Aleagha

Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region

Ischemic stroke is a common leading cause of death and disability with lack of effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression and protein concentration of a...

Authors: Tahmineh Mokhtari, Mohammad Akbari, Fatemeh Malek, Iraj Ragerdi Kashani, Tayebeh Rastegar, Farshid Noorbakhsh, Mahmoud Ghazi-Khansari, Fatemeh Attari and Gholamreza Hassanzadeh

Simultaneous detection of bovine and porcine DNA in pharmaceutical gelatin capsules by duplex PCR assay for Halal authentication

In the pharmaceutical industry, hard- and soft-shelled capsules are typically made from gelatin, commonly derived from bovine and porcine sources. To ensure that pharmaceutical products comply with halal regul...

Authors: Jafar Nikzad, Soraya Shahhosseini, Maryam Tabarzad, Nastaran Nafissi-Varcheh and Maryam Torshabi

New horizons in treatment of osteoporosis

Prevalence of osteoporosis is increasing both in developed and developing countries. Due to rapid growth in the burden and cost of osteoporosis, worldwide, it seems reasonable to focus on the reduction of frac...

Authors: Ozra Tabatabaei-Malazy, Pooneh Salari, Patricia Khashayar and Bagher Larijani

Budget impact analysis of vaccination against Haemophilus influenzae type b as a part of a Pentavalent vaccine in the childhood immunization schedule of Iran

Health decision makers need to know the impact of the development of a new intervention on the public health and health care costs so that they can plan for economic and financial objectives. The aim of this s...

Authors: Fatemeh Teimouri, Abbas Kebriaeezadeh, Seyed Mohsen Zahraei, Mohammadmahdi Gheiratian and Shekoufeh Nikfar

Erratum to: Opportunities and obstacles to the development of nanopharmaceuticals for human use

Authors: Nasser Nassiri Koopaei and Mohammad Abdollahi

Effects of developmental exposure to silver in ionic and nanoparticle form: A study in rats

Evaluations of silver in both nanoparticle (Ag-NPs) and ionic forms indicate some adverse effects on living organisms, but little is known about their potential for developmental toxicity. In this study, devel...

Authors: Mohammad Charehsaz, Karin Sørig Hougaard, Hande Sipahi, Asiye Işın Doğan Ekici, Çiğdem Kaspar, Mustafa Culha, Ülkü Ündeğer Bucurgat and Ahmet Aydin

Opportunities and obstacles to the development of nanopharmaceuticals for human use

Pharmaceutical nanotechnology has generated breakthrough developments in improving health care and human life from its emergence. The biomaterials employed mainly aim at improving drug delivery systems, imagin...

Authors: Nasser Nassiri Koopaei and Mohammad Abdollahi

Pharmacokinetics of calycopterin and xanthmicrol, two polymethoxylated hydroxyflavones with anti-angiogenic activities from Dracocephalum kotschyi Bioss

Recently flavonoids have attracted the attention of researchers in the fight against cancer. Calycopterin and xanthomicrol, are two polymethoxylated flavonoids found in the aerial parts of Dracocephalum kotschyi ...

Authors: Seyedeh-Somayeh Zamani, Mohsen Hossieni, Mahmoud Etebari, Pirooz Salehian and Soltan Ahmad Ebrahimi

Fabrication and biological evaluation of chitosan coated hyaluronic acid-docetaxel conjugate nanoparticles in CD44⁺ cancer cells

Hyaluronic acid (HA) has been used for target-specific drug delivery because of strong affinity to CD44, a marker in which overexpressed in cancer cells and cancer stem cells. Conjugation of HA to the cytotoxi...

Authors: Nazanin Shabani Ravari, Navid Goodarzi, Farhad Alvandifar, Mohsen Amini, Effat Souri, Mohammad Reza Khoshayand, Zahra Hadavand Mirzaie, Fatemeh Atyabi and Rassoul Dinarvand

Aspirin use and bleeding volume in skin cancer patients undergoing surgery: a randomized controlled trial

We investigated the occurrence of bleeding complications in patients who underwent skin tumor surgery and compared it between Aspirin users and a placebo control group. In this double blind randomized controll...

Authors: Arman Engheta, Shahryar Hadadi Abianeh, Ali Atri and Mehdi Sanatkarfar

Erratum to: Women-only drug treatment services and needs in Iran: the first review of current literature

Authors: Zahra Alam-mehrjerdi, Reza Daneshmand, Mercedeh Samiei, Roya Samadi, Mohammad Abdollahi and Kate Dolan

Expression, purification and biological activity assessment of romiplostim biosimilar peptibody

Romiplostim is a peptibody analogue of thrombopoietin (TPO) which regulates platelet production. This molecule consists of two main parts: Peptide sequences which like wild type TPO, mimics stimulation of TPO ...

Authors: Shima Fayaz, Pezhman Fard-Esfahani, Majid Golkar, Mojgan Allahyari and Sedigheh Sadeghi

Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line

Crocin, one of the main constituents of saffron extract, has numerous biological effects such as anti-cancer effects. Multidrug resistance-associated proteins 1 and 2 (MRP1 and MRP2) are important elements in ...

Authors: Shadi Mahdizadeh, Gholamreza Karimi, Javad Behravan, Sepideh Arabzadeh, Hermann Lage and Fatemeh Kalalinia

Comparison between a serum creatinine-and a cystatin C-based glomerular filtration rate equation in patients receiving amphotericin B

Serum cystatin C (Cys C) has a number of advantages over serum creatinine in the evaluation of kidney function. Apart from Cys C level itself, several formulas have also been introduced in different clinical s...

Authors: Iman Karimzadeh and Hossein Khalili

Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis

Sepsis is a debilitating systemic disease and described as a severe and irregular systemic inflammatory reaction syndrome (SIRS) against infection. We employed CLP (Cecal Ligation and Puncture) model in rats t...

Authors: Mehdi Aliomrani, Mohammad Reza Sepand, Hamid Reza Mirzaei, Ali Reza kazemi, Saeid Nekonam and Omid Sabzevari

High azithromycin concentration in lungs by way of bovine serum albumin microspheres as targeted drug delivery: lung targeting efficiency in albino mice

Following administration, the antibiotic travels freely through the body and also accumulates in other parts apart from the infection site. High dosage and repeated ingestion of antibiotics in the treatment of...

Authors: Balakeshwa Ramaiah, Sree Harsha Nagaraja, Usha Ganganahalli Kapanigowda, Prakash Rao Boggarapu and Rajarajan Subramanian

Challenges of access to medicine and the responsibility of pharmaceutical companies: a legal perspective

The right to health as a basic human right- and access to medicine as a part of it- have been a matter of attention for several decades. Also the responsibilities of different parties- particularly pharmaceuti...

Authors: Saeed Ahmadiani and Shekoufeh Nikfar

Preliminary investigation of the effects of topical mixture of Lawsonia inermis L. and Ricinus communis L. leaves extract in treatment of osteoarthritis using MIA model in rats

Many plants have been introduced in Iranian traditional medicine for treatment of different joint problems including knee pain. Topical application of the mixture of Lawsonia inermis L. leaves (Henna) with aqueou...

Authors: Atousa Ziaei, Shamim Sahranavard, Mohammad Javad Gharagozlou and Mehrdad Faizi

Retraction Note: Drying of a plasmid containing formulation: chitosan as a protecting agent

Authors: Nasir Mohajel, Abdolhossein R. Najafabadi, Kayhan Azadmanesh, Alireza Vatanara, Mohsen Amini, Esmail Moazeni, Amirabbas Rahimi and Kambiz Gilani

A model for priority setting of health technology assessment: the experience of AHP-TOPSIS combination approach

In recent times, the use of health technologies in the diagnosis and treatment of diseases experienced considerable and accelerated growth. The goal of the present study was to describe the designated pilot MC...

Authors: Mohammadreza Mobinizadeh, Pouran Raeissi, Amir Ashkan Nasiripour, Alireza Olyaeemanesh and Seyed Jamaleddin Tabibi

Osmolarity: A hidden factor in Nanotoxicology 

In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of ...

Authors: Saeid Moayyedi, Omid Mashinchian and Rassoul Dinarvand

Characterization and pharmacological potential of Lactobacillus sakei 1I1 isolated from fresh water fish Zacco koreanus

There are still a large variety of microorganisms among aquatic animals which have not been explored for their pharmacological potential. Hence, present study was aimed to isolate and characterize a potent lac...

Authors: Vivek K. Bajpai, Jeong-Ho Han, Gyeong-Jun Nam, Rajib Majumder, Chanseo Park, Jeongheui Lim, Woon Kee Paek, Irfan A. Rather and Yong-Ha Park

Does pharmacist-supervised intervention through pharmaceutical care program influence direct healthcare cost burden of newly diagnosed diabetics in a tertiary care teaching hospital in Nepal: a non-clinical randomised controlled trial approach

Cost is a vital component for people with chronic diseases as treatment is expected to be long or even lifelong in some diseases. Pharmacist contributions in decreasing the healthcare cost burden of chronic pa...

Authors: Dinesh Kumar Upadhyay, Mohamed Izham Mohamed Ibrahim, Pranaya Mishra, Vijay M. Alurkar and Mukhtar Ansari

Statistical optimization of tretinoin-loaded penetration-enhancer vesicles (PEV) for topical delivery

The aim of this study was to develop and optimize deformable liposome for topical delivery of tretinoin.

Authors: Neda Bavarsad, Abbas Akhgari, Somayeh Seifmanesh, Anayatollah Salimi and Annahita Rezaie

A novel approach for inventory problem in the pharmaceutical supply chain

In pharmaceutical enterprises, keeping up with global market conditions is possible with properly selected supply chain management policies. Generally; demand-driven classical supply chain model is used in the...

Authors: Gökçe Candan and Harun Reşit Yazgan

Acknowledgement of manuscript reviewers 2015

The editor of DARU Journal of Pharmaceutical Sciences would like to thank all our reviewers who have contributed to the journal in Volume 23 (2015).

Authors: Mohammad Abdollahi, Mohammad Ali Faramarzi, Alireza Foroumadi, Kambiz Gilani, Hossein Khalili, Mahnaz Khanavi, Ali Akbar Moghadamnia, Morteza Mahmoudi, Shekoufeh Nikfar, Ali Nokhodchi, Roja Rahimi, Mohammad Reza Rouini and Alireza Vatanara

Women-only drug treatment services and needs in Iran: the first review of current literature

Iran (Persia) has a women-only drug treatment system. However, literature is not documented. The current study aimed to review the development of women-only drug treatment and harm reduction services (WODTHRS) an...

Authors: Zahra Alam-mehrjerdi, Reza Daneshmand, Mercedeh Samiei, Roya Samadi, Mohammad Abdollahi and Kate Dolan

Comparative Pharmacokinetics of three major bioactive components in rats after oral administration of Typhae Pollen-Trogopterus Feces drug pair before and after compatibility

Typhae Pollen (TP) and Trogopterus Feces (TF) are well-known traditional medicine in china which widely used for thousands of years as drug pair called Shixiao San for treatment of blood stasis syndrome, speci...

Authors: Huiting Zeng, Ping Xue, Shulan Su, Xiaochen Huang, Erxin Shang, Jianming Guo, Dawei Qian, Yuping Tang and Jin-ao Duan